Scientific publications

The objective: to study the level of mRNA expression of the TSC1 and TSC2 genes in peripheral blood leukocytes of patients with chronic pulmonary sarcoidosis and healthy individuals. Subjects and Methods. A total of 58 people were examined, of them 28 people were patients with chronic pulmonary sarcoidosis (stage II of the disease) without treatment, their average age made 42.11±2.21 years, and 30 people were included to Comparison Group (healthy individuals) with the average age of 43.03±1.84 years. Real-time PCR was used to assess the level of mRNA expression of the TSC1 and TSC2 genes in peripheral blood leukocytes (PBL) of patients with pulmonary sarcoidosis and healthy individuals.Results. In the group of patients with sarcoidosis (stage II of the disease), testing peripheral blood leukocytes revealed a significant decrease in expression of mRNA of the TSC1 gene (p=0.007) and a significant increase in the number of transcripts of the TSC1 gene (p=0.0002) compared to healthy individuals matched for age.